Aetiology of multiple sclerosis
نویسندگان
چکیده
منابع مشابه
The complex genetic aetiology of multiple sclerosis.
A large body of immunologic, epidemiologic, and genetic data indicate that tissue injury in multiple sclerosis (MS) results from an abnormal immune response to one or more myelin antigens that develops in genetically susceptible individuals after exposure to an as-yet undefined casual agent. A genetic component in MS is indicated by an increased relative risk to siblings compared to the general...
متن کاملEnvironmental risk factors in multiple sclerosis aetiology.
The epidemiology of multiple sclerosis (MS) has been intensively studied. It is conceptualised as a complex disease in which genetic and environmental factors act together to cause disease. There are temporal and geographic variations in disease risk, and risk of disease may be affected by migration between regions of differing risk. Numerous potential causal factors including infection, immuni...
متن کاملExogeneous factors in the aetiology of multiple sclerosis.
Neuroepidemiology has undoubtedly played a fundamental role in the study of multiple sclerosis (MS) by providing some aetiologic clues, although a definitive basis for the conclusive resolution of its enigma is still lacking. Epidemiological and genetic studies have indicated that MS is probably caused by multiple factors, both genetic and environmental, none of which is individually sufficient...
متن کاملElements: in this month’s issue Aetiology of multiple sclerosis
When patients are given the news that they have a serious and debilitating condition, one of the questions they ask is ‘what caused this, why me?’ In the case of multiple sclerosis (MS) we can say that while we know that for some patients genetic factors certainly play a role, for many we can only offer broad explanations that allude to multifactorial environmental issues in susceptible individ...
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ژورنال
عنوان ژورنال: QJM
سال: 2011
ISSN: 1460-2725,1460-2393
DOI: 10.1093/qjmed/hcr064